| ncRNA name | hsa-miR-34a |
| ncRNA Category | miRNA |
| Disease name | proliferative vitreoretinopathy (PVR) |
| Species | Homo sapiens |
| Tissues/Cell_line | human RPE cell line ARPE-19; human embryonic kidney cell line HEK293 |
| Methods | luciferase reporter assay, immunofluorescent staining, transwell assay, Western blot |
| Expression pattern | down-regulated |
| Functional description | miR-34a gene expression upregulation inhibits ARPE-19 cell proliferation, migration and adhesion partly by suppressing LGR4 expression. Both miR-34a and LGR4 are potential drug targets to prevent fibrosis in a clinical setting. |
| PubMed ID | 27977785 |
| Year | 2016 |
| Title | LGR4 Is a Direct Target of MicroRNA-34a and Modulates the Proliferation and Migration of Retinal Pigment Epithelial ARPE-19 Cells. |
| Drug-related ncRNA | NO |
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